SC-31155 - Santa Cruz Biotechnology

SC-31155 EGFR (N-20)

SANTA CRUZ BIOTECHNOLOGY, INC. www.DataSheet4U.com EGFR (N-20): sc-31155 The Power to Question BACKGROUND The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which fo.

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of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target. APPLICATIONS EGFR (N-20) is recommended for detection of EGF receptor of mouse, rat and human origin by Western Blotting (starting dilution 1:200, dilution range 1:100-1:1000), immunoprecipitation [1
  –2 µg per 100
  –500 µg of total protein (1 ml of cell l.